Agitation Review

Antipsychotics Increased Mortality in a Large Canadian Study

Here. The effect is weak. It likely would not be felt at the clinical level. This large sample included typical neuroleptics. These cause more movement side effects, have greater effects on cardiac function and on blood pressure. The sample did not include any use of aripiprazole nor ziprasidone.

Compared to the risk of agitation, self-injury, and injury to others, this increased risk is small.

Use of Anti-Psychotics in Elderly Demented Patients

Reviewed here. The causes of death were varied and non-specific. The sample size was large. The rate of death was low. The wrong statistical test was applied. Although the risk of death is higher on typical anti-psychotics than on atypicals, the atypicals carry no black box warning. This is the wacko world of the moronic FDA. That agency should be disbanded.

Clozapine for Agitation in Dementia

Retrospective study reviewed here.